Bifidobacterium breve CCFM683 could ameliorate DSS-induced colitis

Bifidobacterium breve CCFM683could ameliorate DSS-induced colitis in mice primarily via conjugated linoleic acid production and gut microbiota modulation

Journal & Pages: Journal of Functional Foods, 2018, 49: 61-72.

Abstract: Probiotics have been proposed as the alternative therapy for IBD, but with strong strain-dependent effects. The current work aims to investigate the protective effect of B. breve CCFM683 on a DSS-induced colitis. CCFM683 significantly inhibited disease activity index, colon shortening and myeloperoxidase activity. Additionally, CCFM683 improved the histological damage, protected the colonic mucous layer integrity and significantly attenuated the expression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), while up-regulated the expression of colonic anti-inflammatory cytokine IL-10 and nuclear receptor PPARγ. Meanwhile, the concentration of colonic conjugated linoleic acid (CLA) was significantly increased in response to CCFM683 supplementation, which demonstrates that CCFM683 prevents colitis in correlation with local CLA production. Furthermore, CCFM683 could rebalance the gut microbial composition damaged by DSS, including reducing the abundance of Romboutsia, Porphyromonadaceae, Desulfovibrionaceae as well as increasing the abundance of Peptostreptococcaceae, which indicated that gut microbiota reconstruction might be another factor for CCFM683 protection against colitis.

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【作者提要】

长期服用改善肠道炎症的药物会造成严重副作用和并发症，而服用短双歧杆菌CCFM683，上调肠道紧密连接蛋白，下调肠道促炎细胞因子，改善紊乱的肠道菌群，缓解结肠炎小鼠的症状；同时该菌可在病灶处原位产生可抑炎的共轭亚油酸CLA，与菌体协同发挥调节肠道炎症的作用，为肠炎的防治提供了新思路。该菌对IBD患者的保护效果正在开展中。

Authors & Affliations:

Bo Yang^a,b,c, Haiqin Chen^a,b,c,*, He Gao^a,b, Juntong Wang^a,b, Catherine Stanton^c,d,e, R. Paul Ross^c,e, Hao Zhang^a,b,c, Wei Chen^a,b,c,f

^a State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China

^b School of Food Science and Technology, Jiangnan University, Wuxi 214122, China

^c International Joint Research Center for Probiotics & Gut Health, Jiangnan University, Wuxi 214122, China

^d Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland

^e APC Microbiome Ireland, University College Cork, Cork, Ireland

^f Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology & Business University, Beijing 100048, China

Link: https：//www.sciencedirect.com/science/article/pii/S1756464618304377