A next generation probiotic, Akkermansia muciniphila

A next generation probiotic, Akkermansia muciniphila

Journal & Pages：Critical Reviews in Food Science and Nutrition, 2019，59(19): 3227-3236.

Abstract：Akkermansia muciniphila, a symbiotic bacterium of the mucus layer, can utilize mucin as its sole carbon, nitrogen, and energy source. As an abundant resident in the intestinal tract of humans and animals, the probiotic effects of A. muciniphila including metabolic modulation, immune regulation and gut health protection, have been widely investigated. Various diseases such as metabolic syndromes and auto-immune diseases have been reported to be associated with the disturbance of the abundance of A. muciniphila. In this review, we describe the biological characterization of A. muciniphia, the factors that influence its colonization of the intestinal tract; and discuss the current state of our knowledge on its role in host health and disease.

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【作者提要】

综述了阿克曼氏菌的菌株特性、免疫调节作用、膳食调节因素及菌株在健康、疾病中的作用。重点条论了阿克曼氏菌缓解肥胖的主要机制：阿克曼氏菌可以通过改善肠道屏障功能，降低高脂膳食诱导的肠道屏障功能损伤及慢性炎症，其表面蛋白Amuc_1100发挥了重要的调节功能。

Authors：

Zhai, QX (Zhai, Qixiao)[ 1,2,3 ] ; Feng, SS (Feng, Saisai)[ 1,2 ] ; Arjan, N (Arjan, Narbad)[ 3,4 ] ; Chen, W (Chen, Wei)[ 1,2,5,6,7 ]

[1] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi, Jiangsu, Peoples R China

[2] Jiangnan Univ, Sch Food Sci & Technol, Wuxi, Jiangsu, Peoples R China

[3] Jiangnan Univ, Int Joint Res Lab Probiot, Wuxi, Jiangsu, Peoples R China

[4] Quadram Inst Biosci, Gut Hlth & Food Safety Programme, Norwich Res Pk, Norwich, Norfolk, England

[5] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi, Jiangsu, Peoples R China

[6] BTBU, Beijing Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China

[7] Jiangnan Univ, Yangzhou Inst Food Biotechnol, Yangzhou, Jiangsu, Peoples R China

DOI：10.1080/10408398.2018.1517725

Published：2019-10-08